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Biology Postdoctoral Fellow Job Opening @ AstraZeneca, Cambridge, UK: Ph.D. / MD in a relevant area of Biology. Extensive knowledge of mitochondrial biology

Biology Postdoctoral Fellow Job Opening @ AstraZeneca, Cambridge

Biology Postdoctoral Fellow Job Opening @ AstraZeneca, Cambridge: At AstraZeneca, we believe in the potential of people who share our passion for science. By thinking boldly and working collaboratively to pursue discoveries beyond imagination, you’ll develop further and faster than you thought possible. We’ll complement your drive and determination to meet unmet patient needs around the world with the inspiration and opportunities to enhance your niche expertise and build your skills. So if you’re curious about what science can do, come and make a difference.

Drug Safety and Metabolism (DSM)

One of the greatest challenges when discovering and formulating effective medicines lies in mapping their pharmacokinetic properties – how they’ll react within the human body. You’ll ensure our drug products are safe for clinical trials, and ultimately safe to deliver as novel treatments to patients. To make that happen, you’ll be working with truly cutting-edge in silico, in vivo, cellular and molecular technologies to push the boundaries of predictive science.

Main duties and responsibilities

This is an exciting opportunity to investigate the interrelationship between mitochondrial bioenergetics, proteome changes, and ultra-structure. This multidisciplinary project will identify the role of cell signalling in regulating mitochondrial dysfunction/remodelling and apoptosis/autophagy, and how this crosstalk is perturbed by small molecules.

You’ll be expected to develop innovative strategies and deliver novel insights into fundamental mechanisms of mitochondrial dysfunction, leading to high impact publications. This will entail close liaison with DSM and other AstraZeneca Cambridge scientists, as well as the MRC Toxicology Unit in Leicester.

Biology Postdoctoral Fellow Job Opening @ AstraZeneca, Cambridge

Essential requirements

  • PhD and/or MD in a relevant area of Biology
  • Extensive knowledge of mitochondrial biology and cutting-edge methodologies
  • Proven experience of the role of mitochondria in regulation of cell death and autophagy
  • Experience in quantitative LC-MS/MS of organelle proteomes.

Desirable requirements

  • Ability to analyse large data sets and metabolic and cell-signalling pathways
  • Relevant experience in hepato/cardiac cell models
  • Experience in fluorescence confocal microscopy and advanced EM ultrastructural imaging

To apply for this position, please click the apply link below.

AstraZeneca is an equal opportunity employer. AstraZeneca will consider all qualified applicants for employment without discrimination on grounds of disability, sex or sexual orientation, pregnancy or maternity leave status, race or national or ethnic origin, age, religion or belief, gender identity or re-assignment, marital or civil partnership status, protected veteran status (if applicable) or any other characteristic protected by law. AstraZeneca only employs individuals with the right to work in the country/ies where the role is advertised.

This is a 2 year Fixed Term Contract opportunity, plus 1 year which will be merit based.  The role will be based at Leicester and Cambridge with a competitive salary on offer

Opening date of advert: 17th February 2017

Closing date of advert: 18th April 2017

Location: UK – Cambridge

Biology Postdoctoral Fellow Job Opening @ AstraZeneca, Cambridge

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