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Chemistry Jobs USA | Scientist position @ Calithera Biosciences - MS or PhD in chemical or biological sciences with a 3 years industrial R & D experience...

Chemistry Jobs USA | Scientist position @ Calithera Biosciences

Chemistry Jobs USA | Scientist position @ Calithera Biosciences: Calithera Biosciences is a clinical-stage pharmaceutical company focused on discovering and developing novel small molecule drugs directed against tumor metabolism and tumor immunology targets for the treatment of cancer.Our lead product candidate in tumor metabolism, CB-839, is an internally discovered, first-in-class inhibitor of glutaminase, a critical enzyme in tumor metabolism. We are currently evaluating CB-839 in three Phase 1 clinical trials in solid and hematological tumors.In tumor immunology, our lead preclinical program is directed at developing inhibitors of the enzyme arginase and may provide a first-in-class therapeutic agent for this novel target. Our ongoing research efforts are focused on discovering additional product candidates against novel tumor metabolism and immunology targets.

Chemistry Jobs USA | Scientist position @ Calithera Biosciences

Primary Responsibilities

  • Conduct analytical method development for drug substance and drug product testing and characterization.
  • Transfer and oversee formal validation at GMP sites.
  • Work with non-clinical and clinical group to support bioanalytical method development and validation.
  • Provide (non-GMP) analytical support for small molecule preformulation, formulation development, stability and other studies.
  • With the drug substance manufacturing and medicinal chemistry teams, develop tests and specifications for all drug candidate molecules.
  • Assist in the identification of impurities and degradants in drug candidates.
  • Develop methods and processes to enrich impurities and degradation products for identification and absolute synthesis of standards.
  • With input from the medicinal chemistry team, direct full analytical characterization of the physicochemical properties of drug candidate molecules.
  • Oversee the transfer of analytical methods to GMP CROs, ensure their implementation, and review all methods and data from in-process and release testing at CROs.
  • Design and support in-house drug substance and drug product stability studies (non-GMP) and manage these activities at GMP CROs.
  • Prepare and characterize formulations for preclinical studies.
  • Develop and apply small molecule preparative HPLC methods
  • Maintain HPLC and other instrumentation
  • Write technical reports as necessary
  • Effectively communicate in oral and/or in written form to internal or external audiences

Requirements:

  • MS or PhD in chemical or biological sciences with a minimum of 3 years relevant industrial research and development experience.
  • Substantial small molecule HPLC and LC-MS method development experience.
  • Independent problem-solving and troubleshooting abilities.
  • Preparative HPLC experience a plus.
  • Basic knowledge of GMPs.
  • Ability to work independently as well as in a team environment.
  • Knowledge of small molecule preformulation and formulation development a plus.
  • Excellent oral and written communication skills.

Chemistry Jobs USA | Scientist position @ Calithera Biosciences

Apply Now: hr@calithera.com

View Original Notification : http://www.calithera.com/about-us/careers/

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