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Evolutionary Biology & Biochemistry 2 PhD Position @ Max Planck Society Germany

Evolutionary Biology & Biochemistry 2 PhD Position @ Max Planck Society Germany

Evolutionary Biology & Biochemistry 2 PhD Position @ Max Planck Society Germany: The Max Planck Society is Germany’s most successful research organization. Since its establishment in 1948, no fewer than 18 Nobel laureates have emerged from the ranks of its scientists, putting it on a par with the best and most prestigious research institutions worldwide. The more than 15,000 publications each year in internationally renowned scientific journals are proof of the outstanding research work conducted at Max Planck Institutes – and many of those articles are among the most-cited publications in the relevant field. Evolutionary Biology & Biochemistry 2 PhD Position @ Max Planck Society Germany

Evolutionary Biology & Biochemistry 2 PhD Position @ Max Planck Society Germany

2 PhD Positions

Max Planck Institute of Biochemistry, Martinsried

Developmental and Evolutionary Biology & Genetics
Immunobiology and Infection Biology & Medicine
Structural and Cell Biology
Physiology
Chemistry
Type of Job: Young Researchers

2 PhD Positions

Evolutionary Biology & Biochemistry 2 PhD Position @ Max Planck Society Germany

Job Offer from June 26, 2017

The Max Planck Institute of Biochemistry has an offer for two PhD Positions (Chromatin as limiting factor in the regulation of DNA repair pathway choice) in the lab of Boris Pfander.

Evolutionary Biology & Biochemistry 2 PhD Position @ Max Planck Society Germany

The project

The stability of the genome is constantly challenged by DNA damage, which is recognized as a driving force in cancer development. DNA repair has to occur within the context of chromatin and chromatin acts both as a barrier and a regulator of DNA repair. We have recently shown for the repair of DNA double strand breaks (DSBs) by homologous recombination that chromatin can be in two states, which are either permissive or restrictive for homologous recombination (Bantele et al. 2017, eLIFE).

In the context of the collaborative research cluster SFB 1064, we aim (I) to characterize these two states (e.g. chromatin-associated factors, histone modifications, etc) in a systems biology approach. Moreover, we aim (II) to use an in vitro reconstituted system to identify the biochemical mechanism of specific chromatin-associated factors that promote or impede repair by homologous recombination. Since these factors determine which pathway is used for the repair of the DSB our findings will reveal how cells control DNA repair pathway choice. These projects will therefore not only give fundamental insights into a basic cell biological mechanism, but also have a critical impact on future gene editing approaches (e.g. CRISPR/Cas9).

Your profile

  • recent degree (MSc or equivalent) in Biochemistry, Biology or a related discipline of the Life Sciences
  • very high interest in basic cell biology
  • independent worker
  • strong commitment and work ethic
  • strong background in lab techniques (project I – molecular cell biology; project II – biochemistry)
  • high interested in interdisciplinary approaches
  • open for international cooperation

Our offer

  • an internationally competitive PhD project in a young, ambitious and successful research team
  • world-leading facilities and experimental support at the Max Planck Institute of Biochemistry
    productive collaborations within the Research Cluster ‘Chromatin Dynamics’ and with international experts in the field of genome stability
  • plentiful opportunities to further develop professional skills within a multi-disciplinary research team
  • a 3-4 year structured PhD program (IRTG) with possible additional courses at the Max Planck Institute of Biochemistry
  • a 65 percent position, pay level TV-L E13

Your application

For specific information about this project and applications, please contact Boris Pfander (bpfander@biochem.mpg.de). The institutions contributing to the CRC 1064 are equal opportunity employers.

Max Planck Institute of Biochemistry
Am Klopferspitz 18
82152 Martinsried
Germany

Evolutionary Biology & Biochemistry 2 PhD Position @ Max Planck Society Germany

View Original Notification: https://www.mpg.de/11371394/2-phd-positions

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