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Gene Therapy Genetics Jobs Scientist Position @ Shire USA

Gene Therapy Genetics Jobs Scientist Position @ Shire USA

 Gene Therapy Genetics Jobs Scientist Position @ Shire USA: Shire is the leading global biotechnology company focused on serving people with rare diseases and other highly specialized conditions. We strive to develop best-in-class products, many of which are available in more than 100 countries, across core therapeutic areas including Hematology, Immunology, Neuroscience, Ophthalmics, Lysosomal Storage Disorders, Gastrointestinal/Internal Medicine/Endocrine and Hereditary Angioedema; and a growing franchise in Oncology.  Gene Therapy Genetics Jobs Scientist Position @ Shire USA

Gene Therapy Genetics Jobs Scientist Position @ Shire USA

Posting Title: Scientist, Gene Therapy Research

Employee Type: Regular

Job Id: 16547BR

Level: SRPR I

Function: R & D Search

Location(s): United States – MA – Lexington

Job Category: Research and Development

Gene Therapy Genetics Jobs Scientist Position @ Shire USA

Primary Role:

The Gene Therapy Scientist is responsible to support Discovery Research internal and external gene therapy programs. The incumbent will represent Discovery Therapeutics Gene Therapy team independently to participate in matrix project teams within Discovery Therapeutics (eg. Protein Engineering, Protein Expression, Analytics and Cell Line Developments) and with other major functions in Research and Non-Clinical Development to advance preclinical drug candidates in a highly collaborative manner. Efforts will contribute to the advancement of drug candidate through early research and early development.



  • Design, conduct hands-on experiments, analysis of results, documentations, preparation of study reports and presentations Works occasionally and effectively with CROs to deliver materials and reagents needed for gene therapy drug development. Ensures compliance of Gene Therapy activities.


  • Represent Discovery Therapeutics Gene Therapy and participate in cross-functional project teams.


  • Follow compliance of documentation in electronic laboratory notebooks.

 Gene Therapy Genetics Jobs Scientist Position @ Shire USA

Education & Experience Requirements:

  • PhD in virology, genetics, pharmacology or related biological science with 3+ years of academic and/or industrial experience. Strong track record of scientific publications is required.
  • Experience in viral vector knowledge is required. Direct experience in the design, utilization and therapeutics development of rAAV vectors are desirable.
  • Experience and proficiency in molecular biology including complex in silico and hands on DNA cloning to design, develop and optimize gene expression cassette for tool and therapeutic viral vectors.
  • Hands on experience in genetics to test gene therapy vectors through the design, planning and execution of preclinical proof-of-concept in vivo experiments in normal and various disease animal models with in-depth understanding of end points measurements in collaboration with internal and external team members.
  • Proficient in extraction and handing of DNA, RNA and/or protein from tissue-culture and animal tissue samples to be used in subsequent experiments.
  • Ability to adapt to new and fast paced environment and navigate uncertainties
  • Expected to work independently with supervision, identify challenges and seek input from colleagues and supervisor for solutions to diverse problems, and demonstrate motivation in pursuing scientific answers through thorough experimental planning
  • Excellent interpersonal communication and written skills for presentations, report writing and day-to-day project team communications.
  • Frequent presentation of study plan and results to the manager, small and/or large group of audience is expected.
  • Ability to design and perform experiments as an individual or in a team setting.
  • Data-driven, critical thinking, analytical and ability to interpret results with statistical approaches.

Our employees come to work every day with a shared mission: to develop and deliver breakthrough therapies for the hundreds of millions of people in the world affected by rare diseases and other high-need conditions, and who lack effective therapies to live their lives to the fullest.

To Apply: https://sjobs.brassring.com/tgwebhost/jobdetails.aspx?partnerid=25300&siteid=5445&jobid=1165145

 Gene Therapy Genetics Jobs Scientist Position @ Shire USA

View Original Notification: https://www.shire.com/careers/open-positions/job-detail?jd=16547br

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