Home / Jobs / Biomedical Engineering Jobs / Genetic BioEngineering PhD Position @ Ku Leuven Belgium
Genetic BioEngineering PhD Position @ Ku Leuven Belgium

Genetic BioEngineering PhD Position @ Ku Leuven Belgium

Genetic BioEngineering PhD Position @ Ku Leuven Belgium: The University of Leuven was founded at the centre of the historic town of Leuven in 1425, making it Belgium’s first university. After being closed in 1797 during the Napoleonic period, the Catholic University of Leuven was “re-founded” in 1834, and is frequently, but controversially, identified as a continuation of the older institution.A In 1968 the Catholic University of Leuven split into the Dutch-language Katholieke Universiteit Leuven and the French-language Université catholique de Louvain, which moved to Louvain-la-Neuve in Wallonia.

Genetic BioEngineering PhD Position @ Ku Leuven Belgium

GENETIC AND THERAPEUTIC DEPENDENCIES OF PATIENT-DERIVED MODELS OF BRAIN CANCER
(Ref. DOCO-2017-11)
Place: Leuven
Last date: 31/03/2017

At the Laboratory for Precision Cancer Medicine (part of the Translational Cell & Tissue Research Unit), we are looking for a highly motivated student with a medical, biomedical, bioengineering, biology or alike background to do a PhD.

GENETIC AND THERAPEUTIC DEPENDENCIES OF PATIENT-DERIVED MODELS OF BRAIN CANCER

Attention! Financing for this position is not guaranteed, but will need to be applied for with the support of a supervisor at a scholarship organization. Applying to this position will bring you in contact with a potential supervisor.
The laboratory of Precision Cancer Medicine is a young team within the Translational Cell and Tissue Research Unit at the department of Imaging and Pathology (KULeuven). The research unit of Translational Cell and Tissue Research consists of 11 pathologists who provide expert pathology consultancy to the affiliated University Hospitals Leuven (campus Gasthuisberg), in addition to two full time research professors, including Prof. Frederik De Smet. Through a close collaboration with the Neurosurgery and Oncology departments of the University Hospitals Leuven, this department is ideal to do translational research on high grade brain cancer.
Project

Glioblastoma (GBM) is the most common and aggressiveprimary central nervous system malignancy with a median survival of about 15months upon maximal standard-of-care therapy. Even though the geneticaberrations of GBM have been studied extensively, treatment options remainlimited and very inefficient.

To speed up the identification of alternativetherapeutic approaches, in vitrostudies on cancer cell lines offer a valid strategy. However, many establishedcancer cell lines, which are commonly used in cancer research for which theyhave been cultured for several decades, have drifted away from their originalphenptype and therefore often poorly represent clinical phenotypes.Patient-derived tumor cell lines, which are cultured for only brief periods oftime, are therefore gaining traction as novel, more representative cancermodels.

At the laboratory for Precision Cancer Medicine, weare developing a “living tissue bank” of well-characterized, short-culturedpatient-derived GBM cancer cell lines that maximally preserve phenotypic andgenomic fidelity and heterogeneity. These lines are derived from clinical biopsiesof GBM (newly diagnosed and/or recurrent), all collected at the UniversityHospitals Leuven (about 50/year). Each successfully expanded cell line (beyondpassage 3) is fully characterized using state-of-the-art genetics and pathologyand compared to the tumor of origin. As such, we are developing the firstBelgian collection of well-characterized patient-derived brain cancer cell lines,which traps the unique genetic and phenotypic features of each individualpatient. With the availability of this collection, the goal is now to determinethe genetic and therapeutic dependencies of each of these lines.

Projectproposal

Theprimary goal of this project is to perform functional analyses of thepatient-derived cancer cell lines by: (i) identifying the patient-specific, geneticdriver events using the CRISPR/Cas9 technology (i.e. genetic dependencies),and (ii) measuring responses to existingand novel therapies (i.e. therapeutic dependencies). The combination of thefunctional responses will be correlated to the clinical information of eachpatient to gain fundamental, therapeuticand diagnostic insights into the disease mechanisms of high-grade braincancer.

This will beachieved by combining state of the art with standard laboratorytechniques. The student will have the opportunity to work in aninternational environment on exciting and clinically very relevant topics. The feasibility of this topical project will beensured by the unique and close collaboration of both clinical (UZLeuven) and fundamental (KULeuven) research experts.

Profile

  • We are looking for a motivated student with a medical, biomedical, bioengineering, biology or alike training to enrol into a PhD project.
  • Experience in doing cell culture, biochemical assays, genetic analysis and drug screening is a plus.

Offer

We are looking for students who can apply for various national (e.g. FWO, KUL) and international fellowships (e.g. Marie-Curie).

Interested?

For more information please contact Prof. dr. Frederik De Smet, mail: frederik.desmet@kuleuven.be or Mrs. Annelies Claeys, mail: annelies.claeys@kuleuven.be.
You can apply for this job no later than March 31, 2017 via the online application tool

Genetic BioEngineering PhD Position @ Ku Leuven Belgium

View Original Notification: https://icts.kuleuven.be/apps/jobsite/vacatures/54084192

Check Also

Biology PhD Student Position Available @ Ghent University Belgium

Biology PhD Student Position Available @ Ghent University Belgium

Biology PhD Student Position Available @ Ghent University Belgium: Ghent University is a top 100 …

BioChem Adda is made possible by displaying online advertisements to our visitors.
Please consider supporting us by disabling your ad-blocker.
%d bloggers like this: