Home / Jobs / Biochemistry Jobs / Immunology Jobs USA | Scientist Position @ Calithera Biosciences
Immunology Jobs USA | Scientist Position @ Calithera Biosciences

Immunology Jobs USA | Scientist Position @ Calithera Biosciences

Immunology Jobs USA | Scientist Position @ Calithera BiosciencesCalithera Biosciences is a clinical-stage pharmaceutical company focused on discovering and developing novel small molecule drugs directed against tumor metabolism and tumor immunology targets for the treatment of cancer. Our lead product candidate in tumor metabolism, CB-839, is an internally discovered, first-in-class inhibitor of glutaminase, a critical enzyme in tumor metabolism. We are currently evaluating CB-839 in three Phase 1 clinical trials in solid and hematological tumors. In tumor immunology, our lead preclinical program is directed at developing inhibitors of the enzyme arginase and may provide a first-in-class therapeutic agent for this novel target. Our ongoing research efforts are focused on discovering additional product candidates against novel tumor metabolism and immunology targets.

Immunology Jobs USA | Scientist Position @ Calithera Biosciences

Duties and Responsibilities

  • Design, develop, and optimize cell-based and biochemical assays to enable the evaluation of lead compounds designed to stimulate immune related anti-tumor activity.
  • Conduct mechanism of action studies using immune cell co-culture platforms to uncover cellular pathways that are modulated by small molecule inhibitors.
  • Design and perform drug combination studies to identify compounds whose mechanism of action synergize to effect a desired cellular response.
  • Collaborate actively with other scientists to identify and evaluate new discovery programs.

Qualifications:

  • PhD in immunology, biology, biochemistry or related discipline is preferred with a minimum of 2 years post-doctoral or pharma/biotech experience.
  • Demonstrated hands-on experience with designing, executing and analyzing biochemical and cell-based mechanism of action experiments.
  • Experience with isolation of human PBMCs and immune cell separation techniques for in vitro cell-based assays.
  • Experience in the use of flow cytometry to analyze immune cell subsets including rare cell types.
  • Experience setting up co-culture assays with immune cells or other immune cell functional assays is required.
  • Pharmacodynamic assay development experience is highly desirable.
  • Highly motivated with excellent problem solving abilities.
  • Breadth and flexibility to adapt to changing project needs .
  • Good communication, interpersonal, organizational, and leadership skills are essential.

Immunology Jobs USA | Scientist Position @ Calithera Biosciences

Apply Now : hr@calithera.com

View Original Notification- http://www.calithera.com/about-us/careers/

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