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Molecular Biology Careers | PhD Position @ DKFZ

Molecular Biology Careers | PhD Position @ DKFZ: The German Cancer Research Center (DKFZ) in Heidelberg is Germany’s largest biomedical research institute. As part of the Helmholtz Association, the largest research organization in Germany, the DKFZ has an international and dynamic work environment, providing scientists with access to state-of-the-art research facilities and exceptional resources.

More than 2,800 employees in over 90 divisions and research groups carry out research to unravel the causes and mechanisms of cancer development and to identify novel tools for diagnosis, treatment and prevention. With Harald zur Hausen (2008) and Stefan Hell (2014), two researchers of the DKFZ have been awarded the Nobel Prize.

Molecular Biology Careers | PhD Position @ DKFZ

Department: Neuropeptides

Designation: PhD Student – Oxytocin and cortictropin releasing hormone circuits regulated by homeodomain-containing protein Otp

code: 099/2016

Your tasks: This PhD project is from the German-Israeli Helmholtz Research School in Cancer Biology, a joint PhD training initiative of the German Cancer Research Center and the Weizmann Institute of Science in Rehovot, Israel.

The successful candidate will be required to spend 6-12 months during their PhD working at the Weizmann Institute (in the laboratory of our collaborator, Prof. Gil Levkowitz). For further information about the Research School, please refer to the website: https://www.dkfz.de/en/phd-program/GIHRS.html

The homeodomain-containing protein Otp is an important development factor, however its role in the adult CNS remains unknown, however ther are few indications that Otp regulates the hypothalamic response to homeostatic challenge. The goal of this proposal is the elucidation of the mechanism of action by which the transcription factor Otp mediates the molecular and behavioral response to stressful stimuli. In particular, we will focus on the role of Otp in two principle neurohormones involved in stress- corticotropin-releasing hormone (CRH) and oxytocin (OXT).

There are two aims of the proposal:

1) To determine the role of the Otp gene in the establishment of wiring within the central OT and CRH systems
2) To elucidate the role of Otp gene in the activity of OT and CRH system during stress response

These aims will able addressed by using available transgenic animals carrying floxed Otp gene, Cre-expressing transgenic mice and various viral vectors. The mice will be subjected to behavioral experiments combained with opto- and pharmacogenetic manipulations of OT and CRH neurons.

Your profile:

1. Experience in standard molecular biological techniques (cell culture, cloning and PCR)
2. Experience in standard anatomical techniques (perfusion, sectioning, immunoihistochemical staining)
3. Experience working with animals (handling, simple behavioral tests)

The successful candidate will be required to spend 6-12 months during their PhD working at the Weizmann Institute, Rehovot, Israel.

We offer:

  • Interesting, varied position
  • International environment
  • Compensation to TV-L
  • Opportunities for part-time work
  • Flexible working hours
  • Good education and training

Starts: as soon as possible

Expiration: The position is initially limited to 3 years.

Application deadline: June 30, 2016

Further information: Dr. Valery Grinevich

phone 06221 42-1581

Apply Online

Molecular Biology Careers | PhD Position @ DKFZ

View original notification: http://www.dkfz.de/en/stellenangebote/index.php?id=099/2016

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