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Oncology BioChemistry Research Associate Job @ Novartis USA

Oncology BioChemistry Research Associate Job @ Novartis USA

Oncology BioChemistry Research Associate Job @ Novartis USA: Novartis has a focused strategy, strong culture and a clear mission to discover new ways to improve and extend people’s lives. We use science-based innovation to address some of society’s most challenging healthcare issues and find new ways to deliver breakthrough treatments to as many people as possible.

Oncology BioChemistry Research Associate Job @ Novartis USA

Job ID: 189118BR

Posting Title: BS/MS Research Associate: Oncology Biochemistry

Division: NIBR

Business Unit: Oncology NIBR

Country: USA

Work Location: Cambridge, MA

Company/Legal Entity: NIBRI

Functional Area: Research & Development

Therapeutic/Disease Area: Oncology

Job Type: Full Time

Employment Type: Regular

Job Description:

The Molecular Pharmacology and Biological Chemistry (MPBC) group is an early stage drug discovery team within Oncology research at NIBR, focused on understanding and exploiting the molecular mechanisms of novel cancer targets for the discovery, characterization and optimization of small molecule therapeutics. We are seeking a highly motivated, creative and collaborative scientist to join our team in a hands-on role to discover the next generation of innovative cancer treatments.

Responsibilities for the role include:

  • Generation of protein reagents from cloning through purification using multiple expression systems to support mechanistic biochemical studies of potential drug targets
  • Design, development and troubleshooting of diverse biochemical and biophysical assays for use in the assessment of both mechanism and small molecule modulation of cancer targets, including hit identification, validation and optimization
  • Analysis, interpretation, documentation and presentation of data to local groups and project teams
  • Contribution to group knowledge and expertise through collaboration and idea exchange with multidisciplinary teams

EEO Statement

The Novartis Group of Companies are Equal Opportunity Employers and take pride in maintaining a diverse environment. We do not discriminate in recruitment, hiring, training, promotion or any other employment practices for reasons of race, color, religion, gender, national origin, age, sexual orientation, marital or veteran status, disability, or any other legally protected status.

Minimum requirements

  • BA/BS or MS degree in Biochemistry, Biophysics, Enzymology or a related field with 3+ years of relevant experience
  • Extensive knowledge of molecular biology, protein expression (E. coli, baculovirus and mammalian expression systems) and protein purification as well as protein analytical skills (e.g. gel electrophoresis, Western blotting, and size exclusion chromatography) are required; experience with AKTA Pure, Explorer or other similar FPLC is a must.
  • Experience with protein characterization techniques such as SEC-MALS, DLS, DSF, CD, peptide mapping by LC/MS/MS, post translational modification identification, etc. is required.
  • A solid understanding of protein function and enzyme characterization using biochemical and biophysical techniques including fluorescence-based assay techniques (e.g. HTRF, FP) and label-free technologies (e.g. SPR, ITC, DSC, LC-MS) for protein target and small molecule inhibitor characterizations as well as protein-ligand binding interactions is preferred.
  • Demonstrated ability to analyze, interpret and present data in a clear manner
  • Excellent communication and inter-personal skills

At NIBR we believe that along with our scientists, our culture is our greatest asset. To drive that culture each employee is expected to function in an innovative and collaborative manner. Each successful candidate will be able to demonstrate how they have functioned in this manner to drive results.

Oncology BioChemistry Research Associate Job @ Novartis USA

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