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PhD Medical Science Position @ Gothenburg University | Sweden

PhD Medical Science Position @ Gothenburg University | Sweden

PhD Medical Science Position @ Gothenburg University | Sweden: The University of Gothenburg tackles society’s challenges with diverse knowledge. 37 000 students and 6 000 employees make the University a large and inspiring place to work and study, with a continuous flow of new knowledge and ideas. Strong research and attractive study programmes attract scientists and students from around the world. The University of Gothenburg is environmentally certified and works actively for sustainable development. With new knowledge and new perspectives, the University contributes to a better future.

PhD Medical Science Position @ Gothenburg University | Sweden

PhD student position in medical science – Development of mucosal vaccines and adjuvants
Type of employment: Fixed-term employment, 4 years
Extent: 100 %
Location: Sahlgrenska Academy, Gothenburg
First day of employment: As agreed
Reference number: UR 2016/610
Project title
Development and characterization of recombinant mucosal vaccine antigens and adjuvants

Job assignments
The project deals with problems surrounding the production of vaccine components based on cholera toxin. Firstly, this involves production of the non-toxic B subunit of cholera toxin (CTB) which is a component of an oral killed whole cell cholera vaccine that significantly increases the level of protection. To produce an affordable cholera vaccine this component has to be produced in a recombinant system based on Vibrio cholerae. The system must deliver robust production from a stable background that does not require antibiotics to maintain expression plasmids. Secondly, cholera toxin (CT) is the most powerful mucosal adjuvant known but is far too toxic for human use. It is proposed to generate a non-toxic, adjuvant-active CT derivative and to test it in different immunization models. Finally, the group is engaged in the generation of fusion proteins in which specific antigens are attached to CTB. A number of these are of potential clinical interest and systems for their production are needed that can be scaled up for GPM production and use in phase I clinical trials as well as pre-clinical testing in animals.

The successful candidate will develop the skills, knowledge and insight in order to contribute to the development and production of a variety of vaccines and vaccine components. The vaccines in question will be either an oral killed whole cell vaccine against cholera under development in our laboratory or therapeutic vaccines based on the non-toxic cholera B subunit of cholera toxin that aim to modulate and suppress harmful in flammatory immune responses in a number of auto-immune diseases. By the end of the project the student will have confidence to independently perform genetic manipulations and modifications of gram-negative bacteria, clone and express recombinant proteins, run medium scale fermentations in bioreactors, purify recombinantly produced proteins from bacteria or from culture medium, analyze the purity and integrity of purified recombinant proteins, perform standard immunological assays and assist in the analysis of immune responses in immunized experimental animals.

The PhD position comprises 4 years full-time studies and leads to a doctoral degree. The position is funded via doctoral studentship.

To be admitted to third-cycle studies you must fulfill both the general and the specific entry requirements. The general entry requirements is fulfilled if you have:

  • completed a degree at a second-cycle level, or
  • completed at least 240 credits worth of studies of which at least 60 credits must be at a second-cycle level, or
  • acquired equivalent knowledge in some other way in Sweden or abroad.

The specific entry requirements is fulfilled if you have completed the English B/6 course or is considered to have acquired equivalent knowledge through previous studies.

Regulations for the evaluation of qualifications for education on a doctoral level are given in SFS 1998:80.

In selecting between applicants who meet the general and specific entry requirements, their ability to benefit from third-cycle studies shall be taken into account. The assessment shall attach particular importance to documented qualifications for:

  • specific knowledge and skills within the subject area and related research fields
  • experience of scientific theory and relevant research methodology
  • scientific analysis and presentation verified through thesis, degree project, scientific journals or the like.

Additional information
Salaries for doctoral students are regulated in a local agreement at the University.

For more information about the project please contact the project supervisor, contact information can be found on the top right corner.

For more information regarding PhD education at the Sahlgrenska academy visit http://www.sahlgrenska.gu.se/doktorandportalen

If you have technical difficulties or questions regarding the application database contact rekrytering@gu.se


Related information

For further information please contact

Michael Lebens, Institute of Biomedicine
+46 31 7866236


Labour union

OFR/S: Peter Brandt
+46 31 786 11 69

SACO: Catrine Folcker
+46 31 786 4234

SEKO: Lennart Olsson
+46 31 786 1173

Closing date: 2016-08-08

Apply online: https://gudok.gu.se/E-rek_CV/Login.aspx?Dnr=773374

Attach verified copies of your education and English proficiency proving your eligibility.

The University of Gothenburg promotes equal opportunities, equality and diversity.


PhD Medical Science Position @ Gothenburg University | Sweden

View Original Notification: http://www.gu.se/english/about_the_university/announcements-in-the-job-application-portal/?languageId=0&disableRedirect=true&id=19144&Dnr=773374&Type=E

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