PhD Scientist / Sr Scientist Bioconjugates @ Magenta Therapeutics: Magenta Therapeutics is a biotechnology company harnessing the power of stem cell science to revolutionize stem cell transplantation for patients with immune and blood-based diseases. By creating a platform focused on critical areas of transplant medicine, Magenta Therapeutics is pioneering an integrated approach to stem cell therapies to create patient benefits. Founded by internationally recognized leaders in stem cell transplant medicine, Magenta Therapeutics was launched in 2016 by Third Rock Ventures and Atlas Venture and is headquartered in Cambridge, Mass. For more information, please visit

PhD Scientist / Sr Scientist Bioconjugates @ Magenta Therapeutics

Position Overview

The Biotherapeutics group at Magenta Therapeutics is looking for an individual experienced in bioconjugation, purification and characterization of complex bioconjugates to play an important role in the discovery and development of transformative biotherapeutics for hematopoietic stem cell transplant.  S/he will be responsible for bioconjugation activities to produce novel antibody drug conjugates (ADCs).  In this capacity, s/he will work cross-functionally as part of internal multi-disciplinary teams, as well as working with external partners and CROs.  S/he will be expected to participate in experimental design and plannng, conduct experiments, maintain detailed records, and communicate results.

Primary Responsibilities:

  • Synthesis, purification and characterization of ADCs on research and early development scales.
  • Development and optimization of conjugation protocols utilizing novel chemistries and technologies.
  • Represent the bioconjugation group as a member of multidisciplinary project teams
  • Identify and manage projects with external collaborators and CROs.
  • Record and communicate findings in a timely manner.

PhD Scientist / Sr Scientist Bioconjugates @ Magenta Therapeutics


  • A PhD in Biochemistry, Chemistry or related discipline with 2+ years of industrial experience is preferred. Qualified MS candidates should have at least 5 years of industrial experience in a drug discovery and development setting.
  • Previous experience in the discovery and development of ADCs, including hands-on experience with the conjugation process is required.
  • Candidate should be able to work independently, learn and optimize new conjugation techniques.
  • Candidates with good working knowledge in analytical techniques including HIC, SEC, RP-HPLC and capillary electrophoresis are preferred.
  • Knowledge and experience in laboratory scale purification using various types of column chromatography and tangential flow filtration is desired.
  • Experience in the processes and requirements for moving ADCs from discovery to development to IND (including writing IND reports, patent applications) is desirable.
  • Proven ability in collaborating effectively within cross-functional teams
  • Excellent analytical, communication, organizational and presentation skills essential.
  • Must be able to deliver in a timeline-driven, fast-paced, start-up environment.

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