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Research Associate Biochemical Engineering Jobs @ UCL | UK

Research Associate Biochemical Engineering Jobs @ UCL | UK

Research Associate Biochemical Engineering Jobs @ UCL | UK. The UCL Department of Biochemical Engineering leads one of the examplar projects on increasing the speed of biocatalyst discovery, development and application. UCL is one of the leading international centres for bioprocess research in the Industrial Biotechnology sector. It has excellent research facilities including a new £2.5M suite of synthetic biology and biocatalysis laboratories and a full-scale £25m bioprocessing pilot plant.

Research Associate Biochemical Engineering Jobs @ UCL | UK

Research Associate in Enzyme Cascades to Alkaloids
Grade: 7

Hours: Full Time

Salary (inclusive of London allowance): £33,686 – £40,716 per annum

Closing Date: 25 July 2016

Duties and Responsibilities

The Research Associate will work with Professor Helen Hailes in the Department of Chemistry and Professor John Ward in the Department of Biochemical Engineering at University College London. This collaborative project aims to design and assemble de novo pathways in vitro and in vivo for the synthesis of novel complex alkaloids with new functionalities. Non-natural substrates will be used as starting materials to generate diverse alkaloids,inspired by the plethora of alkaloid natural products but targeting distinct and novel structures not seen in nature.

The postholder will be required to clone and over-express new functional enzymes including norcoclaurine synthases, tyrosine hydroxylases and decarboxylases, methyl transferases and cytochrome P450s. They will make mutant libraries of key enzymes and develop enzymes screens and the assay methodologies to determine enzyme selectivities against compounds. Chemical products will be purified and characterised and the postholder will establish chiral assays for the determination of enzyme stereoselectivities. They will also use selected enzymes in multistep in vitro cascades and an in vivo syntheticbiology pathway to demonstrate the range of potential chemistries achievable. The postholder will work in a multi-disciplinary environment so excellent team-working and communication skills will be required.

The appointment is funded by the BBSRC for 3 years initially.

Key Requirements

The successful candidate must have a PhD (or be about to be awarded a PhD) n a relevant discipline (Chemistry, Chemical Biology, Biological Chemistry, Biochemistry, Molecular Biology or equivalent) and possess experience in several of the following areas: enzyme cloning and expression, site-directed mutagenesis, biocatalysis, enzyme screening and assay development, and organic synthesis, compound purification and characterisation.

Please note, appointment at Grade 7 is dependent upon having been awarded a PhD; if this is not the case, initial appointment will be at Research Assistant Grade 6 (salary £29,485 – £31,091 per annum) with payment at Grade 7 being backdated to the date of final submission of the PhD thesis.

Research Associate Biochemical Engineering Jobs @ UCL | UK

Further Details

How to apply:

To apply for the vacancy please visit: www.ucl.ac.uk/hr/jobs and search ref:1562209

The Job Description and Person Specification can be accessed at the bottom of this page.

Contacts

Further details about the vacancy are available from Prof. Helen Hailes (email: h.c.hailes@ucl.ac.uk).

Any queries on the application process should be directed to Judith James (email: j.k.james@ucl.ac.uk).

 

View Original Notification: https://www.ucl.ac.uk/chemistry/vacancies

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