Sr./Principal Research Associate, Protein Expression, and Purification @ Moderna Therapeutics

The Role:
Moderna Therapeutics is seeking a Sr./Principal Research Associate to join the Protein Sciences group at our Cambridge, MA site. The candidate will participate in both platform technology and Moderna therapeutic area projects by expressing, purifying, and characterizing recombinant proteins and antibodies. Specifically, the candidate will design protein expression constructs, develop and optimize robust FPLC-based protein purification processes, characterize purified material using standard biochemical techniques (e.g., SDS-PAGE, size-exclusion chromatography) and develop/execute enzymatic activity assays. The candidate will also be responsible for basic FPLC maintenance and training other associate-level researchers in recombinant protein production.

Sr./Principal Research Associate, Protein Expression, and Purification @ Moderna Therapeutics

Here s What You ll Do:

  • Design bacterial and eukaryotic protein expression constructs
  • Test and optimize expression conditions
  • Purify proteins using FPLC-based methods (e.g., affinity and ion exchange chromatography)
  • Characterize proteins using standard biochemical techniques (e.g., western blot, thermal melt, size-exclusion chromatography)
  • Develop enzyme activity assays (spectrophotometric/fluorimetric, LC/MS-based, etc.)
  • Establish workflows (expression, purification and screening) for high-throughput protein engineering projects
  • Analyze, interpret and troubleshoot experiments
  • Mentor Research Associates in protein purification

Here s What You ll Bring to the Table:

  • BS/MS or equivalent in Chemistry, Biochemistry, or Bioengineering-related field with 5+ years of experience in protein expression and purification
  • Experience with bacterial, insect and mammalian expression systems
  • Experience in basic molecular biology techniques (plasmid propagation, cloning and sequencing)
  • Experience with KTA programming
  • Experience in biochemical characterization of proteins (e.g., western blot, thermal melt)
  • Experience with antibodies preferred
  • Experience with enzyme activity assays and enzyme kinetics preferred
  • Ability to work independently on complex experiments
  • Ability to collaborate closely with multiple cross-functional project teams
  • Ability to multi-task to meet technology development and research goals
  • Strong quantitative analysis skills as well as excellent written and oral communication
  • C andidate will be curious in exploring new path for drug discovery, bold in proposing creative experimental designs and ideas. Will work collaboratively with multifunctional teams and will be relentless in pursuing successful outcomes

Here s What We ll Bring to the Table:

  • Daily on-site catered lunches
  • Company-provided iPhone
  • Free parking, monthly subway pass or a subsidized commuter rail pass.
  • Highly competitive healthcare coverage. Including: medical offered through BCBS (HMO/PPO), dental, and vision offered through VSP
  • Flexible Spending Accounts for medical expenses and dependent care expenses.
  • 401k (traditional and Roth offered) with 50% match on first 6% deferred. Match is vested immediately.
  • A suite of Moderna paid insurance coverage, including life insurance, short-term and long-term disability
  • Voluntary legal assistance plan
  • 15 days vacation and 7 sick days per year, in addition to a discretionary winter shut down and 11 company paid holidays.
  • Adoption assistance, competitive parental leave, discount to local childcare centers, as well as access to

Why join Moderna Therapeutics

We are pioneering a new class of medicines made of messenger RNA, or mRNA. The potential implications of using mRNA as a drug are significant and far-reaching. It could transform not only how certain diseases are treated but also how medicines are discovered, developed and manufactured at a breadth, scale and speed not common in the biopharma industry.

Since our founding in 2011, we have built the industry s leading mRNA technology platform , the infrastructure to accelerate drug discovery and speed early development, a rapidly expanding pipeline , and an unparalleled team . Our development pipeline includes development candidates for mRNA-based vaccines and therapies spanning several therapeutic areas, and we have multiple clinical trials already underway with other development candidates progressing toward the clinic. In addition, we have a number of discovery programs that are advancing toward the development stage.

We invite you to explore our site to learn more about our company and how we are advancing the promise of mRNA science to improve health and impact lives around the world.

Our Mission:
Deliver on the promise of mRNA science to create a new generation of transformative medicines for patients.


Moderna is committed to equal employment opportunity and non-discrimination for all employees and qualified applicants without regard to a person s race, color, gender, age, religion, national origin, ancestry, disability, veteran status, genetic information, sexual orientation or any characteristic protected under applicable law. Moderna will make reasonable accommodations for qualified individuals with known disabilities, in accordance with applicable law.

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