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Structural Biology Jobs | Senior Research Scientist @ inStem: Ph.D. in structural biology (x-ray crystallography) or related field is required..............

Structural Biology Jobs | Senior Research Scientist @ inStem

Structural Biology Jobs | Senior Research Scientist @ inStem: The Institute for Stem Cell Biology and Regenerative Medicine (inStem), is a state-of-the-art research institute in Bangalore, India, dedicated to the study of stem cell and regenerative biology. An autonomous institute funded by the Dept of Biotechnology, Govt. of India, inStem emphasizes collaborative research in stem cell biology. inStem’s mandate to allow this cross-disciplinary, multi-pronged approach to research, straddles the divide between clinical and laboratory research in stem cell biology. In trying to answer intractable and challenging questions that face the field, inStem seeks to rewrite the paradigm of the research institute: without barriers and across disciplines.

Senior Research Scientist

KNOWLEDGE, EXPERIENCE AND SKILLS:

  • Ph.D. in structural biology (x-ray crystallography) or related field is required
  • At least 4-6 years of academic/industry experience with a record of important contributions to development of project is required
  • Recognized scientific expertise in structural biology along with peer reviewed publications is required
  • Strong record of success in employing Structure Based Drug Design (SBDD) and Fragment Based Lead Discovery (FBLD/FBDD) approaches utilizing x-ray crystallography are required
  • Broad drug discovery background, with knowledge of biophysics, biochemistry, and protein sciences are required
  • Outstanding leadership capabilities
  • Experience in working with external research organizations, including contract research organizations, and/or public-private consortia is preferred
  • Experience in scientific programming (Unix shells, Python, Perl), and ability to work with the latest relevant software packages and in a mixed Linux/Windows computational environment is preferred

Structural Biology Jobs | Senior Research Scientist @ inStem

DUTIES AND JOB FUNCTIONS:

  • Ensure timeliness and accuracy of the results and of written reports. Organize and prioritize work performed in the laboratory
  • Expedite the completion of projects and ensure that appropriate turn-around goals are met. Perform troubleshooting of problems with procedures, methods and protocols in all aspects of molecular and structural biology
  • Monitor and assure that appropriate procedures of protein crystallography are followed for quality control and quality assurance and that proper documentation is logged in
  • Give presentations to the group members as well as at educational workshops of the department
  • Support protein design, expression and purification to support small-molecule discovery
  • Biophysical characterization of proteins and protein-ligand complexes to facilitate protein crystallization and protein science studies (e.g. DLS, ITC, DSC, fluorescence, NMR)
  • Design of protein constructs for SBDD and protein sciences experiments
  • Lead determination of high quality protein structures and co-crystal structures through crystallization, data collection and refinement
  • Communicating effectively with medicinal and computational chemists to translate hit to leads
  • Familiarity with up-to-date laboratory safety protocols and employ them in the course of all work
  • Assist senior researchers in executing, conducting analysis and reporting results
  • Familiarity with literature and internal best practices to identify opportunities to improve productivity and quality of work
  • Participate in research discussions with members of the research teams in a highly collaborative research environment
  • Knowledge of X-ray data collection and structure determination methods
  • Experience of high throughput structural methodologies
  • Experience with automated systems, including crystallization plate setup and crystal imaging robotics
  • Works relatively independently on assigned tasks

HOW TO APPLY: Interested candidates may send in the following information by email to jobs-ccbt@instem.res.in

  • Curriculum Vitae (CV)
  • Publication list
  • Contact details of three professional referees

Date of Posting: 22-06-2016

Structural Biology Jobs | Senior Research Scientist @ inStem

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