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Veterinary Medicine PhD Position @ Bern University | Switzerland

Veterinary Medicine PhD Position @ Bern University | Switzerland

Veterinary Medicine PhD Position @ Bern University | Switzerland: The University of Bern offers top quality across the board: it enjoys special recognition in leading-edge disciplines, is reputed for the excellent quality of its teaching, offers a delightful setting, and a campus environment intimately linked to the social, economic and political life of the city.

Veterinary Medicine PhD Position @ Bern University | Switzerland

The Clinical Immunology Group at the Department of Clinical Research and Veterinary Public Health of the Vetsuisse-Faculty of the University of Bern is seeking motivated applicants for a

PhD student position

Responsibilities

Equine insect bite hypersensitivity (IBH) is an IgE-mediated allergic dermatitis in horses caused by bites of insects of the genus Culicoides and represents a natural model for human skin allergies. Beside its function as physical barrier, the skin has been recognized as an important immune organ. Keratinocytes can contribute significantly to the initiation of an allergic immune response, through cytokines and other mediators which influence the response of dendritic cells, which in turn link the innate to the acquired immunity. However, whether and how the allergen-induced response of keratinocytes and of dendritic cells differs between allergic and non-allergic individuals is not yet elucidated. The aims of the project are to study the role of keratinocytes and dendritic cells in the pathogenesis of IBH and to contribute to the development of an effective immunotherapy for the control and prevention of IBH in horses.

Description:

The present PhD project will focus on the role of keratinocytes and dendritic cells in the development of allergy or tolerance in IBH. Major allergens for IBH will be expressed as recombinant proteins. Primary keratinocyte cultures from skin of IBH-affected horses and of healthy control horses will be established and stimulated with the relevant allergens. The transcriptome from primary keratinocyte cultures and skin dendritic cells from IBH-affected and control horses stimulated with Culicoides allergens will be compared.
The project will be performed in collaboration with the Molecular Dermatology and Stem Cell Research Group and the NGS and bioinformatics core units of the University of Bern.

Requirements

  • Applicants must hold a European degree in Veterinary Medicine or an academic degree in Natural Sciences (MSc or equivalent) to be acceptable for registration as a PhD student at a Swiss University. Students will have to be admitted to the Graduate School for Cellular and Biomedical Sciences at the University of Bern (http://www.gcb.unibe.ch).
  • Experience in either cell culture, molecular biology, bioinformatics or flow cytometry would be an advantage.

Further information

The salary will be according to the guidelines of the Swiss National Science Foundation: http://www.snf.ch/SiteCollectionDocuments/allg_doktorierende_e.pdf

How To Apply:

Please send your application (single PDF file) by e-mail to: eliane.marti@vetsuisse.unibe.ch

Applications should include a letter of interest including a brief statement of your specific qualification for this position , a CV, copies of diplomas, and the names and contact details of two references.
http://www.ekf.vetsuisse.unibe.ch/forschung/klinische_immunologie_eliane_marti/index_ger.html

 

Veterinary Medicine PhD Position @ Bern University | Switzerland

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