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Yeast System Biotechnology PhD Job @ TU Delft Netherlands

Yeast System Biotechnology PhD Job @ TU Delft Netherlands

Yeast System Biotechnology PhD Job @ TU Delft Netherlands: The Faculty of Applied Sciences is the largest faculty of TU Delft, with around 550 scientists, a support staff of 250 and 1,800 students. The faculty conducts fundamental, application-oriented research and offers scientific education at the bachelor, master and doctoral levels. The faculty is active in the fields of Life and Health Science & Technology, Nanoscience, Chemical Engineering, Radiation Science & Technology, and Applied Physics.

Yeast System Biotechnology PhD Job @ TU Delft Netherlands

Yeast System Biotechnology PhD Job @ TU Delft Netherlands

PhD in Yeast Systems Biotechnology
Department/faculty: Applied Sciences
Level: Master degree
Working hours: 38 hours per week
Contract: 4 years
Salary: €2191 to €2801

Applied Sciences

The Department of Biotechnology engages in research in the fields of biocatalysis, bioprocess engineering, cell systems engineering, environmental biotechnology, industrial microbiology, and biotechnology and society. The department offers a stimulating environment in the biosciences, combining fundamental research, engineering, and design, all directed towards biotechnological process innovations. The department moved recently to a brand-new building, which also houses the Bionanoscience and Chemical Engineering departments. Working in such close proximity facilitates inter-departmental collaborations on multidisciplinary projects.

The Cell Systems Engineering group focuses on the quantitative analysis of microbial metabolism, its regulation and kinetics. This is achieved by interdisciplinary approaches, ranging from assay deveopment and bioreactor cultivation to extensive modelling approaches for data interpretation.

 

Job description

In industrial fermentations, poor mixing results in highly dynamic conditions in nutrients and oxygen availability, which complicates rational metabolic engineering and scale-up of the process. In this project, we will combine (13C) metabolomics and real-time, compartment-specific metabolite sensors with enzyme activity measurement and (phospho)proteomics. Together with advanced dynamic modelling the aim is to monitor, model and master the dynamics of yeast central metabolism at an unprecedented scale. The experimental data and models will deliver an operational understanding of glycolysis, pentose phosphate pathways, trehalose and glycogen metabolism, TCA cycles and oxidative phosphorylation, under dynamic nutrient and oxygen feeds.
The 3MYeast project is hiring three PhD students at the different project partners, one at the VU (Teusink), one at the TU Delft (Wahl) and one at TU Eindhoven (van Riel; modelling).
The aim of the project in Delft is to (1) develop metabolic labelling sensors that will allow compartment-specific labelling enrichment measurements, (2) perform dynamic bioreactor cultivations that mimic industrial fermentation conditions, and (3) observe the metabolic response of the microorganism to these conditions using metabolic tracer experiments. You will share your data and observations with the project partners and engage in industrial and academic collaboration.

Requirements

  • We are looking for a highly motivated, critical, and ambitious PhD candidate with a background and experience in microbial physiology, biotechnology, biochemical engineering or biochemistry.
  • The candidate has experience in – or affinity with – both experimental and computational approaches.
  • You are eager to work in a research consortium in a multidisciplinary and dynamic setting.
  • You are flexible and willing to travel and work in different labs.

Conditions of employment

The TU Delft offers a customisable compensation package, a discount for health insurance and sport memberships, and a monthly work costs contribution. Flexible work schedules can be arranged. An International Children’s Centre offers child care and an international primary school. Dual Career Services offers support to accompanying partners. Salary and benefits are in accordance with the Collective Labour Agreement for Dutch Universities.

As a PhD candidate you will be enrolled in the TU Delft Graduate School. The TU Delft Graduate School provides an inspiring research environment; an excellent team of supervisors, academic staff and a mentor; and a Doctoral Education Programme aimed at developing your transferable, discipline-related and research skills. Please visit http://graduateschool.tudelft.nl/ for more information.

To Apply:

Information and application

For more information about this position, please contact S.A. Wahl, phone: +31 (0)15-2783193, e-mail: s.a.wahl@tudelft.nl. To apply, please e-mail a detailed CV along with a letter of application by 31 March 2017 to Ms. Jenifer Baptiste,
secr-cse-tnw@tudelft.nl.

When applying for this position, please refer to vacancy number TNWBT17-002.

Yeast System Biotechnology PhD Job @ TU Delft Netherlands

View Original Notification: http://www.tudelft.nl/en/about-tu-delft/working-at-tu-delft/

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